Diseases

Giant Platelet Syndrome

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Giant platelet syndrome(bernard-soulier syndrome): this condition is a primary problem of platelets in which the platelets lack the ability to stick adequately to injured blood vessel walls and as a result of this problem there is abnormal bleeding.

SYMPTOMS

Abnormality of the abdomen, nosebleeds, heavy menstrual bleeding, purpura, too few platelets circulating in the blood, and prolonged bleeding time have also been listed as symptoms of various giant platelet disorders.

CAUSES

Caused by auto-immune disorders, for example immune thrombocytopenic purpura (itp), and characterized by low platelet count, but high mpv (mean-platelet volume).Caused by Glycoprotein abnormalities: bernard-soulier syndrome, velocardiofacial syndrome. Caused by Calpain defect: montreal platelet syndrome.