Non Alcoholic Steatonercrosis

Nash is a condition characterised by a necroinflammatory component in hepatic macrovesicular steatosis. It is also known as, and is part of a spectrum variously called, non alcoholic fatty liver disease (nafld), pseudo alcoholic liver disease, fatty liver hepatitis steatonecrosis and diabetic hepatitis. Histologically it resembles alcoholic hepatitis with inflammatory changes together with a widespread accumulation of large fat vesicles within liver cells. By definition, alcohol abuse is excluded as a cause. Although it has been reported to be found in 6% of autopsies, it was only brought into clinical prominence by a major clinical report in 1980 (1). The icd 10cm code is k76.0.

SYMPTOMS

Nash causes histologic liver damage similar to that in alcoholic hepatitis but occurs in patients who are not alcoholics and who often are obese or have type 2 diabetes mellitus or dyslipidemia. Symptoms are usually absent, but some patients have right upper quadrant discomfort, fatigue, and/or malaise.

CAUSES

Nash today is the third most common cause of chronic liver disease in north america after alcoholic liver disease and hepatitis c1 and the most common cause of raised transaminases more than six-months. alcoholic fatty hepatitis,7steatonecrosis and diabetic hepatitis.